This qualitative research study aims to understand how plurisexual (bisexual, pansexual) young women and girls (aged 15 – 24) in Quebec, Canada use cannabis to maintain or improve their mental well-being. As awareness of and attitudes towards diverse sexual identities have evolved in Quebec, adolescents, both cis and trans, are adopting plurisexual identities in increasing numbers. Unfortunately, plurisexual adolescents also face biphobia and bi-erasure, that impact their mental well-being and access to support services. Changes in legislation and broader socio-cultural norms in Canada have made cannabis products far more accessible, including for adolescents who are under the legal age to possess or purchase cannabis. Some research has identified both negative and positive impacts of cannabis use on mental well-being, such as enhancing or alleviating anxiety, among other sexual and gender minority populations (mainly focusing on gay and queer men). However, little is known about how cannabis features in the experiences of plurisexual adolescent girls and young women. This project will use in-depth interviews and digital diary techniques with a sample of 15 young women and girls to describe how patterns and contexts of cannabis use are experienced with a focus on mental well-being and will characterize motivations for cannabis use including experiences with isolation and coping. Digital diaries provide a low-barrier approach to longitudinally assess experiences of cannabis use and mental wellness. Results will be used to advance insights into providing mental wellness- and substance use-related care for plurisexual adolescent girls in Quebec, including by bringing the findings to participants, key community groups and service providers.